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Stars represent the critique status, or the level of evaluation supporting the submitted (SCV) document. This benefit is calculated by NCBI according to data from your submitter.

The amount of variants in ClinVar for this gene, together with scaled-down variants throughout the gene and larger CNVs that overlap or totally have the gene.

ClinVar consists of an entry for this variant (Variation ID: 574387). Variants that disrupt the consensus splice site are a comparatively prevalent reason behind aberrant splicing (PMID: 17576681, 9536098). Algorithms created to forecast the impact of sequence modifications on RNA splicing propose that this variant may possibly develop or strengthen a splice web site. In summary, the accessible proof is at this time insufficient to find out the function of the variant in illness. Consequently, it has been categorised like a Variant of Unsure Importance. Alright

Stars signify the mixture critique position, or the extent of evaluation supporting the mixture germline classification for this VCV report.

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This day represents the last time this VCV history was up to date. The update might be due to an update to among the list of involved submitted information (SCVs), or because of an update that ClinVar made to your variant for instance incorporating HGVS expressions or even a rs amount.

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